The genome provides instructions for synthesis of proteins and non-coding RNAs.1 The epigenome provides further instructions on where to express a protein or RNA as well as how much of each to synthesize.1-3 Dysregulation of the epigenome in cancer cells may lead to aberrant gene expression of oncogenes and decreased expression of tumor suppressor genes.1-3
Celgene is developing a diverse array of therapeutics to target all major components of the cancer epigenome.
Roy DM, Walsh LA, Chan TA. Protein Cell. 2014;5:265-296. PMID: 24622842
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