Cell division requires that a parent cell’s chromosomes are aligned and separated equally to opposite poles of the cell before the center of the cell is pinched in to ultimately create 2 separate daughter cells. The complex interplay involved in each of these steps requires a highly dynamic process of microtubule assembly and disassembly.
Taxanes, an established and active class of cytotoxic drugs, disrupt microtubule dynamics to prevent proper cell division, which leads to cell death.1-6 Development efforts on intravenous taxane formulations have led to the use of albumin instead of chemical solvents for drug delivery to improve clinical benefit.7
The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.
Abraxane for injectable suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) [package insert]. Summit, NJ: Celgene Corporation; 2013.
Abraxane for injectable suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) [summary of product characteristics]. Uxbridge, UK: Celgene Europe Limited; 2013.
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