Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid malignancies characterized by multilineage cytopenias and risk of progression to acute myeloid leukemia.1,2 Patients with MDS often have recurring cytogenetic abnormalities3 and somatic mutations4 and exhibit widespread aberrant DNA hypermethylation.5 In addition to the accumulation of genetic and epigenetic abnormalities in myeloid progenitor cells, MDS disease pathogenesis is also driven by defects in the bone marrow microenvironment that further contribute to dysregulation of hematopoiesis.6

Myelodysplastic Syndromes Mechanism of Disease

Myelodysplastic syndromes are a diverse group of bone marrow disorders that can be associated with ineffective erythropoiesis

References

  1. Cazzola M, Malcovati L. N Engl J Med. 2005;352:536-538. PMID: 15703418
  2. Heaney ML, Golde DW. N Engl J Med. 1999;340:1649-1660. PMID: 10341278
  3. Schanz J, et al. J Clin Oncol. 2012;30:820-829. PMID: 22331955
  4. Haferlach T, et al. Leukemia. 2014;28:241-247. PMID: 24220272
  5. Figueroa ME, et al. Blood. 2009;114:3448-3458. PMID: 19652201
  6. Bulycheva E, et al. Leukemia. 2015;29:259-268. PMID: 25394715