Non-Hodgkin lymphomas (NHLs) represent a clinically and genetically heterogeneous group of lymphoproliferative disorders that arise in mature B lymphocytes and T lymphocytes or natural killer cells.1,2 Among the B-cell NHLs, the more common forms include follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL).1 FL is characterized by an indolent course of disease, whereas DLBCL and MCL exhibit a more aggressive clinical course of disease.3-5 T-cell lymphomas also comprise a heterogeneous group of hematologic malignancies, which include peripheral T-cell lymphomas and cutaneous T-cell lymphoma.6,7 The molecular pathogenesis of NHLs is driven by a variety of chromosomal abnormalities and somatic mutations that alter the epigenetic landscape, gene expression, and cellular function of lymphocytes.3-8Testing for the presence of specific proteins on the surface of B and T cells (ie, immunophenotyping) is important in the diagnosis of NHLs.1,9
Explore a 3-D lymph node cross section to review disease pathogenesis and diagnostic criteria for the sub-types of non-Hodgkin lymphoma. Share this interactive resource with your patients to further their understanding of the disease.
The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated